braf - definitie. Wat is braf
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Wat (wie) is braf - definitie

WIKIMEDIA DISAMBIGUATION PAGE
BRAF (disambiguation)

braf         
Falls somewhere between driving on the road and offroading. Basically, driving on grass, dirt, gravel, or mud.
There's a big mud puddle between us and the road. Let's braf it.
BRAF (gene)         
  •  Figure 2: Base-catalyzed nucleophilic attack of a serine/threonine substrate residue on the γ-phosphate group of ATP. Step 1: chelation of secondary magnesium ion by N581 and deprotonation of substrate Ser/Thr by D576. Step 2: nucleophilic attack of activated substrate hydroxyl on ATP γ-phosphate. Step 3: magnesium complex breaks down and D576 deprotonates. Step 4: release of products.
  • Figure 1: Inactive conformation of B-Raf kinase (CR3) domain. P-Loop (orange) hydrophobic interactions with activation loop (gray) residues that stabilize the inactive kinase conformation are shown with sticks.  F595 (red) blocks the hydrophobic pocket where the ATP adenine binds (yellow).  D576 (orange) is shown as part of the catalytic loop (magenta).  Figure modified from PDB id 1UWH.
  •  Figure 3: B-Raf kinase domain locked in the inactive conformation by bound BAY43-9006. Hydrophobic interactions anchor BAY43-9006 in the ATP binding site while urea group hydrogen-bonding traps D594 of the DFG motif.  The BAY43-9006 trifluoromethyl [[phenyl]] ring further prohibits DFG motif and activation loop movement to the active confermer via steric blockage.
  • Figure 4: Structures of Vemurafenib (right) and its precursor, PLX 4720 (left), two inhibitors of the active conformation of the B-Raf kinase domain
PROTEIN-CODING GENE IN THE SPECIES HOMO SAPIENS
V-raf murine sarcoma viral oncogene homolog B1; B-raf 1; BRAF1; Braf1; BRAF gene; B-RAF; Braf inhibitor; BRAF inhibitor; B-Raf inhibitor; PanRAF inhibitor
BRAF is a human gene that encodes a protein called B-Raf. The gene is also referred to as proto-oncogene B-Raf and v-Raf murine sarcoma viral oncogene homolog B, while the protein is more formally known as serine/threonine-protein kinase B-Raf.
V600E         
GENETIC VARIANT
BRAF V600
V600E is a mutation of the BRAF gene in which valine (V) is substituted by glutamic acid (E) at amino acid 600. It is a driver mutation in a proportion of certain diagnoses, including melanoma, hairy cell leukemia, papillary thyroid carcinoma, colorectal cancer, non-small-cell lung cancer, Langerhans cell histiocytosis, Erdheim–Chester disease (a non-Langerhans-cell histiocytosis) and ameloblastoma.

Wikipedia

BRAF

BRAF may refer to:

  • Baton Rouge Area Foundation
  • BRAF (gene)